Da Jian Zhong Tang comes from Zhang Zhongjing's Treatise on Febrile Diseases and Miscellaneous Diseases in the Han Dynasty. It is a prescription designed by Zhang Zhongjing to treat the symptom of "abdominal distension and pain". The main function of this prescription is to "warm the middle and replenish the deficiency, reduce adverse effects and relieve pain". It is mainly used to treat severe chest and abdominal pain (severe cold pain) caused by deficiency and weakness in the middle burner and excessive cold in the body, nausea and vomiting, poor appetite, coldness in the abdomen, sounds in the abdomen, white and slippery tongue coating, and tight pulse.

Explanation of the recipe of Da Jian Zhong Tang
Da Jian Zhong Tang is composed of four Chinese herbs, which can be explained as follows according to the grouping of monarch, minister, assistant and envoy:
Main medicine: Sichuan pepper: spicy and hot in nature, it has the effects of warming the middle and dispelling cold, relieving adverse reactions and relieving pain. Zhang Bingcheng believes that "the spicy and hot Sichuan pepper can reach the lungs and kidneys, expel cold and warm the stomach, dispel stagnation and kill insects."
Assistant medicine dried ginger: pungent and hot, warms the middle and dispels cold, harmonizes the stomach and stops vomiting, and helps Sichuan pepper to warm the middle yang, dispel cold and relieve pain.
Auxiliary ginseng : nourishes the spleen, supports the vital energy, and uses glutinous rice sugar to relieve urgency. It can not only enhance the analgesic effect of pepper and ginger, but also restrain their excessive spiciness and dryness. It also has the effect of sweetening and replenishing qi, replenishing deficiency and supporting yang.
The assistant drug is glutinous rice sugar : it can relieve urgency and strengthen the analgesic effect of pepper and ginger, while restraining their excessive spiciness and dryness. It also has the effect of being sweet and slow in replenishing qi, and nourishing deficiency and supporting yang.
This prescription is both warming and tonifying, with warming as the main effect, warming the middle to eliminate yin and cold, and tonifying the middle earth to build up the middle yang . The combination of these four Chinese herbs can make the middle jiao yang sufficient, eliminate yin and cold, and restore the yang of the whole body.

The efficacy of Da Jian Zhong Tang
The specific mechanism of action of Da Jian Zhong Tang includes warming the middle and dispelling cold, replenishing deficiency and relieving pain. The Sichuan pepper and dried ginger in the recipe have the effect of warming the middle and dispelling cold, which can dispel the cold in the body and restore the normal function of the spleen and stomach. Ginseng and glutinous candy have the effect of replenishing deficiency, enhancing the body's positive energy, and relieving pain and discomfort. These drugs work together to warm the middle and replenish deficiency, reduce adverse reactions and relieve pain, thereby achieving the purpose of treating deficiency-cold in the middle burner and excessive cold in the body.
Da Jian Zhong Tang is mainly used to treat weakness in the middle jiao and excess yin and cold in the body, which can lead to severe chest and abdominal pain (severe cold pain), nausea and vomiting, poor appetite, coldness in the abdomen, sounds in the abdomen, white and slippery tongue coating, and tight pulse. Its specific indications include:
Pulse : tight pulse, stringy pulse
Tongue : greasy white coating, stiff tongue, and poor mobility
Pain : epigastric pain, chest tightness and pain, lower abdominal pain, headache, menstrual pain, abdominal pain around the umbilicus, pain in the middle back, testicular pain and swelling, right lower abdominal pain, sternum pain, intercostal nerve pain, left lower abdominal pain, groin pain, pain in the upper chest
Symptoms : Loss of appetite, abdominal mass, nausea, constipation, chest coldness, sweating, night sweats, weight loss, frequent urination, cough, wheezing, diarrhea, cold feet but not hands, vomiting, diarrhea with undigested food

Its main effects include warming the middle and replenishing deficiency, relieving adverse effects and relieving pain. It is particularly suitable for various symptoms caused by weakness of the middle burner and excessive yin and cold inside the body, such as upper abdominal pain, chest tightness and pain, lower abdominal pain, headache, menstrual abdominal pain, etc.
Modern research shows that Da Jian Zhong Tang has shown significant effects in the treatment of various diseases, especially inflammatory bowel diseases. Research by Japanese scholars has found that Da Jian Zhong Tang has an improvement effect on inflammatory bowel diseases, and its popularity is increasing year by year.
In addition, Da Jian Zhong Tang is also used to treat intestinal adhesions, constipation, intestinal hernia pain, intestinal stenosis, biliary ascariasis, intestinal ascariasis obstruction, gastric dilatation, gastroptosis, pancreatitis, appendicitis, peritonitis, kidney stones and many other diseases.
Modern pharmacological studies of Da Jian Zhong Tang have revealed a variety of mechanisms of action, including anti-massage and analgesic, insecticidal and tonic effects. For example, sansho has a local anesthetic effect, ginseng and gelatin have an anti-massage effect on gastrointestinal smoothness, and dried ginger has analgesic, digestive, stomachic and gas-promoting effects.
Ginseng also has the effects of anti-fatigue, increasing red blood cells, white blood cells and hemoglobin, and gelatin has a nourishing effect. These studies further confirm the potential and value of Dajianzhong Decoction in modern medicine.
Pathogenesis of Da Jian Zhong Tang and Spleen Yang Deficiency
The pathogenesis of Da Jian Zhong Tang mainly involves deficiency-cold in the middle jiao and excess cold in the yin. Deficiency-cold in the middle jiao refers to dysfunction of the spleen and stomach, which leads to insufficient yang in the digestive system, thus causing a series of cold symptoms.
Yin-cold excess refers to excessive coldness in the body, which affects the functions of the meridians and internal organs, causing pain and discomfort. This pathogenesis is common in patients with spleen-yang deficiency, who are prone to feeling cold in the abdomen, accompanied by symptoms such as loss of appetite, abdominal pain, and diarrhea12.

In modern medicine, the application of Da Jian Zhong Tang has also been widely studied, especially in inflammatory intestinal diseases and the regulation of intestinal microbiota. Studies have shown that Da Jian Zhong Tang can inhibit the release of inflammatory factors such as TNF-α, IL-1, IL-6, etc., thereby reducing the inflammatory response of the intestine.
In addition, Da Jian Zhong Tangcan also have a positive impact on intestinal health by regulating intestinal microbiota and improving intestinal barrier function.
Causes of Spleen Yang Deficiency
Long-term irregular diet, excessive consumption of cold, greasy, sweet and other foods that are difficult to digest
Emotional factors, such as excessive worry, can also affect the spleen and stomach function and cause spleen yang deficiency.
Overwork, lack of rest or physical weakness after illness can also cause spleen yang deficiency.
Some people are born with spleen yang deficiency, which is called congenital deficiency. This is often caused by the coldness in the mother's womb.
The invasion of exogenous cold and dampness can also cause spleen yang deficiency, so it is easy to have related symptoms of spleen yang deficiency in winter or when it rains.
Methods to improve spleen yang deficiency
The most common Chinese medicine for warming and nourishing the spleen and yang is "Fuzi Lizhong Decoction"
Some people eat lamb hotpot during the winter, which is a quick way to warm up the body.
Maintaining a regular schedule, ensuring adequate sleep, and frequently tapping the spleen and stomach meridians are the core methods to improve spleen yang deficiency.
Modern research and application of Da Jian Zhong Tang
Modern pharmacological studies have shown that Da Jian Zhong Tang has significant effects in treating postoperative intestinal obstruction (POI), Crohn's disease (CD), and constipation. These studies reveal the potential of Da Jian Zhong Tang in regulating intestinal function and relieving intestinal inflammation, making it an effective prescription for treating a variety of digestive system diseases.

Relieves spasms and pain
Sansho : has local anesthetic effect
Ginseng and gelatin : have a smooth and anti-spasmodic effect on the gastrointestinal tract
Dried ginger : relieves pain, aids digestion, strengthens the stomach, and promotes gas discharge
Insecticidal effect
Sansho : has obvious insecticidal ability against roundworms
Ginseng : It also has an inhibitory effect on gastrointestinal parasites.
Tonic effect
Ginseng : Anti-fatigue, has the effect of promoting the increase of red blood cells, white blood cells and hemoglobin
Gel : nourishing
In addition, Da Jian Zhong Tang also shows a positive effect in regulating intestinal microbiota. Studies have found that Da Jian Zhong Tang can increase the abundance of beneficial bacteria such as Clostridium and Lactococcus lactis in the intestine, thereby improving intestinal health. This regulatory effect helps maintain the balance of intestinal microbiota, further supporting its application in the treatment of intestinal diseases.
Da Jian Zhong Tang is very popular in Japan, mainly because Japanese scholars have found that this recipe has an improvement effect on inflammatory bowel diseases. The composition of this recipe can also be regarded as a kind of food therapy and medicinal diet recipe.
The modern application of Da Jian Zhong Tang also extends to other areas, such as the treatment of depression. Studies have shown that when Da Jian Zhong Tang is used in combination with ketamine, it can improve depressive symptoms through multiple mechanisms. This combination therapy demonstrates the versatility and potential value of Chinese herbal prescriptions in modern medicine, and provides new ideas for the combination of Chinese and Western medicine.
Notes
This prescription should not be used if there is internal accumulation, damp heat, or yin deficiency and blood deficiency. This prescription should not be used if there is abdominal pain caused by internal accumulation of excess heat, damp heat, or yin deficiency and blood heat.
Conclusion
Da Jian Zhong Tang is a traditional Chinese medicine prescription with a long history and remarkable efficacy. It is mainly used to treat various symptoms caused by weakness of the middle jiao and excessive coldness in the body. Its modern application is wide-ranging, especially in Japan, where it has a significant effect on inflammatory bowel diseases. However, when using this prescription, attention should be paid to its indications and contraindications to ensure safety and effectiveness. By understanding the concept and improvement methods of spleen yang deficiency, Da Jian Zhong Tangcan be better understood and applied to protect the health of modern people.